Primarily a figurative painter, Pamela has worked in many other mediums, including photography, printmaking, and assemblage. She received her MFA from the University of California, Santa Barbara, where she was awarded a Regents Fellowship, the Abrams Project Grant, and a Regents Award for her Thesis Exhibition

Pamela has earned a reputation for paintings which transcend the ordinary. She develops haunting images that evoke moods, dreams, and memories inspired by real life, and which create a remarkably compelling narrative. The physical and emotional isolation of her characters has emerged as a hallmark of her work

Descriptions of her work such as "'lost, odd, mad,' or similar terms denoting something out of alignment with ordinary reality. She believes that letting ourselves explore the inherent “distortions” in reality is part of what gives us heart, and balance.

Pamela chooses to address beauty in her paintings as a psychological moment "revolving around the dark and hilarious absurdities we endure while creating ourselves."

Exhibiting since 1992, Wilson's work has been the subject of eighteen solo shows from New York City to California; and she has exhibited in many museums including the National Museum of Women in the Arts, in Washington, DC.

Her paintings are collected by celebrity patrons including Tom Skerrit, Joe Panteleone, Whoopie Goldberg and Howard Tullman.